Continuous Glucose Monitoring in Hypoxic Environments Based on Water Splitting-Assisted Electrocatalysis

Conventional enzyme-based continuous glucose sensors in interstitial fluid usually rely on dissolved oxygen as the electron-transfer mediator to bring electrons from oxidase electrode while generating hydrogen peroxide. This may lead several problems. First, sensor provide biased detection results owing fluctuation of fluid. Second, polymer coatings that regulate glucose/oxygen ratio can affect dynamic response sensor. Third, oxidation reaction continuously produces corrosive peroxide, which compromise long-term stability Here, we introduce an oxygen-independent nonenzymatic based water splitting-assisted electrocatalysis for monitoring. For splitting (i.e., evolution reaction), a negative pretreatment potential is applied produce localized alkaline condition at surface working subsequent electrocatalytic glucose. The process does not require participation oxygen; therefore, problems caused by be avoided. exhibits acceptable sensitivity, reliability, and biocompatibility monitoring hypoxic environments, shown vitro vivo measurements. Therefore, believe it promising technique monitoring, especially clinically patients.